HIV Impairs Opsonic Phagocytic Clearance of Pregnancy-Associated Malaria Parasites

  title={HIV Impairs Opsonic Phagocytic Clearance of Pregnancy-Associated Malaria Parasites},
  author={Jessica Keen and Lena Serghides and Kodjo Ayi and Samir N. Patel and John M Ayisi and Anne Maria van Eijk and Richard W. Steketee and Venkatachalam Udhayakumar and Kevin C Kain},
  journal={PLoS Medicine},
  pages={162 - 171}
BACKGROUND Primigravid (PG) women are at risk for pregnancy-associated malaria (PAM). Multigravid (MG) women acquire protection against PAM; however, HIV infection impairs this protective response. Protection against PAM is associated with the production of IgG specific for variant surface antigens (VSA-PAM) expressed by chondroitin sulfate A (CSA)-adhering parasitized erythrocytes (PEs). We hypothesized that VSA-PAM-specific IgG confers protection by promoting opsonic phagocytosis of PAM… CONTINUE READING


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