HIV-Host Interactions: Implications for Vaccine Design.

  title={HIV-Host Interactions: Implications for Vaccine Design.},
  author={Barton F Haynes and George M. Shaw and Bette T Korber and Garnett H. Kelsoe and Joseph Sodroski and Beatrice H. Hahn and Persephone Borrow and Andrew J McMichael},
  journal={Cell host & microbe},
  volume={19 3},
Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of HIV type 1 (HIV-1), which is a consequence of its propensity to mutate to escape immune responses, along with host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine development. Breakthroughs in understanding of the biology of the transmitted virus, the structure and nature of its envelope trimer, vaccine-induced CD8 T cell control in primates, and host… CONTINUE READING
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