HIV-HBV coinfection in Southern Africa and the effect of lamivudine- versus tenofovir-containing cART on HBV outcomes.

@article{Hamers2013HIVHBVCI,
  title={HIV-HBV coinfection in Southern Africa and the effect of lamivudine- versus tenofovir-containing cART on HBV outcomes.},
  author={Raph L. Hamers and Hans L. Zaaijer and Carole Lorraine Wallis and Margaret Siwale and Prudence D Ive and Mariette E. Botes and Kim Catherina Eve Sigaloff and Andy Hoepelman and Wendy S. Stevens and Tobias F. Rinke de Wit},
  journal={Journal of acquired immune deficiency syndromes},
  year={2013},
  volume={64 2},
  pages={174-82}
}
BACKGROUND This study assessed HIV-hepatitis B virus (HBV) coinfection in southern Africa in terms of prevalence, viral characteristics, occult HBV, and the effect of lamivudine- versus tenofovir-containing first-line combination antiretroviral treatment (cART) on HBV-related outcomes. METHODS A multicenter prospective cohort of HIV-infected adults in Zambia and South Africa who initiated cART. Outcomes by month 12 on cART were immunological recovery, hepatitis B surface antigen (HBsAg) loss… CONTINUE READING
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