HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.

@article{WilleReece2005HIVGP,
  title={HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.},
  author={Ulrike Wille-Reece and Barbara Flynn and Karin Lor{\'e} and Richard A. Koup and Ross M Kedl and Joseph J Mattapallil and Walter R. Weiss and Mario Roederer and Robert A. Seder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 42},
  pages={
          15190-4
        }
}
Induction and maintenance of antibody and T cell responses will be critical for developing a successful vaccine against HIV. A rational approach for generating such responses is to design vaccines or adjuvants that have the capacity to activate specific antigen-presenting cells. In this regard, dendritic cells (DCs) are the most potent antigen-presenting cells for generating primary T cell responses. Here, we report that Toll-like receptor (TLR) agonists and ligands that activate DCs in vitro… CONTINUE READING
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