HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC

@article{Wood2009HIVEI,
  title={HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC},
  author={Natasha Wood and Tanmoy Bhattacharya and Brandon F Keele and Elena 4 Giorgi and Michael K.P. Liu and Brian Gaschen and Marcus G. Daniels and Guido Ferrari and Barton F. Haynes and Andrew Mcmichael and George M. Shaw and Beatrice H. Hahn and Bette T Korber and Cathal Seoighe},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={e1000033 - 281}
}
The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced by the newly transmitted virus. For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape from common early immune responses, could represent adaptation for rapid growth in a newly infected host, or could represent reversion from less fit forms of the virus that were… CONTINUE READING

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