HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC

  title={HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC},
  author={Natasha Wood and Tanmoy Bhattacharya and Brandon F Keele and Elena 4 Giorgi and Michael K.P. Liu and Brian Gaschen and Marcus G. Daniels and Guido Ferrari and Barton F. Haynes and Andrew Mcmichael and George M. Shaw and Beatrice H. Hahn and Bette T Korber and Cathal Seoighe},
  journal={PLoS Pathogens},
  pages={e1000033 - 281}
The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced by the newly transmitted virus. For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape from common early immune responses, could represent adaptation for rapid growth in a newly infected host, or could represent reversion from less fit forms of the virus that were… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 67 references

Models of coding sequence evolution

Briefings in Bioinformatics • 2009
View 1 Excerpt

Identification and Optimal Definition of HIV-Derived Cytotoxic T Lymphocyte (CTL) Epitopes for the Study of CTL Escape, Functional Avidity and Viral Evolution

N Frahm, B Baker, C Brander
View 1 Excerpt

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 10 Excerpts

Current concepts: An HIV vaccine

MI Johnston, AS Fauci
Evolving concepts. New England Journal of Medicine • 2007
View 1 Excerpt

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