HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable.

@article{Rosa2011HIVDNAPA,
  title={HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable.},
  author={Stephen C. De Rosa and Evan P. Thomas and John K Bui and Yunda Huang and Allan C. deCamp and Cecilia Morgan and Spyros A. Kalams and Georgia D. Tomaras and Rama S Akondy and Rafi Ahmed and C Lau and Barney S. Graham and Gary J. Nabel and M Juliana McElrath},
  journal={Journal of immunology},
  year={2011},
  volume={187 6},
  pages={3391-401}
}
Many candidate HIV vaccines are designed to primarily elicit T cell responses. Although repeated immunization with the same vaccine boosts Ab responses, the benefit for T cell responses is ill defined. We compared two immunization regimens that include the same recombinant adenoviral serotype 5 (rAd5) boost. Repeated homologous rAd5 immunization fails to increase T cell responses, but increases gp140 Ab responses 10-fold. DNA prime, as compared with rAd5 prime, directs long-term memory CD8(+) T… CONTINUE READING

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