HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells

@article{Price2005HIV1VP,
  title={HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells},
  author={Tulin Otamis Price and Nuran Ercal and Ryota Nakaoke and William A. Banks},
  journal={Brain Research},
  year={2005},
  volume={1045},
  pages={57-63}
}
The blood-brain barrier (BBB) has an important role in the development of AIDS dementia. The HIV-1 envelope glycoprotein (gp120) and transregulatory protein (Tat) of HIV-1 are neurotoxic and cytotoxic and have been implicated in the development of HIV dementia. They are known to cause oxidative stress and are associated with disruption of the BBB. Here, we used an immortalized endothelial cell line from rat brain capillaries, RBE4, to determine whether gp120 and Tat can induce oxidative stress… 
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