HIV-1 tat transcriptional activity is regulated by acetylation.

@article{Kiernan1999HIV1TT,
  title={HIV-1 tat transcriptional activity is regulated by acetylation.},
  author={Rosemary Kiernan and Caroline Vanhulle and Lou Schiltz and Emmanuelle Adam and Hua Xiao and Fr{\'e}d{\'e}ric Maudoux and Claire Calomme and Ars{\`e}ne Burny and Yoshihiro Nakatani and K T Jeang and Monsef Benkirane and Carine Van Lint},
  journal={The EMBO journal},
  year={1999},
  volume={18 21},
  pages={6106-18}
}
The human immunodeficiency virus (HIV) trans- activator protein, Tat, stimulates transcription from the viral long-terminal repeats (LTR) through an RNA hairpin element, trans-activation responsive region (TAR). We and others have shown that trans-activator protein (Tat)-associated histone acetyltransferases (TAHs), p300 and p300/CBP-associating factor (PCAF), assist functionally in the activation of chromosomally integrated HIV-1 LTR. Here, we show that p300 and PCAF also directly acetylate… CONTINUE READING
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