HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

@article{Marzio1998HIV1TT,
  title={HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.},
  author={Giuseppe Marzio and Mudit Tyagi and Maria Ines Gutierrez and Mauro Giacca},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={13519-24}
}
In cells infected with HIV type 1 (HIV-1), the integrated viral promoter is present in a chromatin-bound conformation and is transcriptionally silent in the absence of stimulation. The HIV-1 Tat protein binds to a stem-loop structure at the 5' end of viral mRNA and relieves this inhibition by inducing a remodeling of the nucleosome arrangement downstream of the transcription-initiation site. Here we show that Tat performs this activity by recruiting to the viral long terminal repeat (LTR) the… CONTINUE READING
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