HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells.

@article{Hofman1999HIV1TP,
  title={HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells.},
  author={Florence M. Hofman and Po-min Chen and Francesca Incardona and Raphael Zidovetzki and David R Hinton},
  journal={Journal of neuroimmunology},
  year={1999},
  volume={94 1-2},
  pages={28-39}
}
This study focused on the role of the HIV-derived viral protein, tat, in activating central nervous system (CNS)-derived endothelial cells (EC) to produce interleukin-8 (IL-8), a stimulator and chemoattractant for neutrophils and lymphocytes. Human CNS-EC treated with tat (100 ng/ml) demonstrated a 2 to 3 fold upregulation in IL-8 mRNA and protein. Tumor necrosis factor-alpha (TNF) and tat were found to act additively in upregulating IL-8 production. In contrast, transforming growth factor beta… CONTINUE READING