HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.

@article{Mayne1998HIV1TM,
  title={HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.},
  author={Michael Mayne and A C Bratanich and Peng Chen and Farazana Rana and Avindra Nath and Christopher Power},
  journal={Neuroimmunomodulation},
  year={1998},
  volume={5 3-4},
  pages={184-92}
}
Activation and infection by HIV-1 of glial cells and infiltrating macrophages are cardinal features of AIDS-related neurological disease. Tumor necrosis factor-alpha (TNF-alpha) is released by these cell types, and increased TNF-alpha mRNA and protein levels are associated with the development and severity of HIV-induced neurological disease. HIV-1 proteins have been implicated in HIV neuropathogenesis including Tat which has been shown to be a potent inducer of TNF-alpha. We review our data… CONTINUE READING

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