HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients.

@article{Kozal1994HIV1SP,
  title={HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients.},
  author={Michael J. Kozal and Robert W. Shafer and Mark A. Winters and David K. Katzenstein and Elsa Aguiniga and Jodi Halpern and Thomas C. Merigan},
  journal={Journal of acquired immune deficiency syndromes},
  year={1994},
  volume={7 8},
  pages={832-8}
}
The variable rate of disease progression in HIV-1-infected patients treated with zidovudine may be related to certain viral characteristics, such as, antiviral drug resistance, virus burden, and viral syncytium-inducing (SI) capacity. Thirty-two HIV-1-infected patients treated with zidovudine (mean of 34 months) were studied to determine the relationship of SI phenotype and the codon 215 pol gene mutation (a marker of zidovudine resistance) to virus burden and CD4 cell decline. Patients with SI… CONTINUE READING