HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha.

@article{Maciejewski1994HIV1SO,
  title={HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha.},
  author={Jaroslaw Maciejewski and Frank F. Weichold and Neal S. Young},
  journal={Journal of immunology},
  year={1994},
  volume={153 9},
  pages={4303-10}
}
Dysmorphic marrow morphology and bone marrow failure are common in AIDS patients, but the mechanism of HIV-1 effects on blood cell production is unclear. Experiments to test the susceptibility of hematopoietic progenitor cells to HIV-1 infection have led to conflicting results. We found that hematopoietic colony formation by burst-forming units-erythroid and CFU-GM was equivalently inhibited by both active and heat-inactivated, noninfectious virus. Inhibition was dependent on the presence of… CONTINUE READING

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