HIV-1 strain-associated variability in infection of primary neuroglia.

  title={HIV-1 strain-associated variability in infection of primary neuroglia.},
  author={Micheline McCarthy and Jianglin He and Charles Wood},
  journal={Journal of neurovirology},
  volume={4 1},
Qualitative differences among strains of Human Immunodeficiency Virus type 1 (HIV-1) may influence viral infectivity for cells of the central nervous system (CNS) and determine or at least significantly influence the neuropathogenesis of brain infection. In this study, we compared infectivity for these cells in vitro among several different laboratory-adapted HIV-1 strains differing in cellular tropism. These strains included three lymphotropic strains (SF2, NL4-3, and SG3.1), two macrophage… CONTINUE READING