HIV-1 splicing is controlled by local RNA structure and binding of splicing regulatory proteins at the major 5' splice site.

@article{Mueller2015HIV1SI,
  title={HIV-1 splicing is controlled by local RNA structure and binding of splicing regulatory proteins at the major 5' splice site.},
  author={Nancy H Mueller and Ben Berkhout and Atze T. Das},
  journal={The Journal of general virology},
  year={2015},
  volume={96 Pt 7},
  pages={1906-17}
}
The 5' leader region of the human immunodeficiency virus 1 (HIV-1) RNA genome contains the major 5' splice site (ss) that is used in the production of the many spliced viral RNAs. This splice-donor (SD) region can fold into a stable stem-loop structure and the thermodynamic stability of this RNA hairpin influences splicing efficiency. In addition, splicing… CONTINUE READING