HIV-1-specific T cell precursors with high proliferative capacity correlate with low viremia and high CD4 counts in untreated individuals.

@article{Calarota2008HIV1specificTC,
  title={HIV-1-specific T cell precursors with high proliferative capacity correlate with low viremia and high CD4 counts in untreated individuals.},
  author={Sandra Amelia Calarota and Andrea Foli and Renato Maserati and Fausto Baldanti and Stefania Paolucci and Mary A Young and Christos M. Tsoukas and Julianna Lisziewicz and Franco Lori},
  journal={Journal of immunology},
  year={2008},
  volume={180 9},
  pages={5907-15}
}
Evidences have recently suggested that the preservation of vaccine-induced memory rather than effector T cells is essential for better outcome and survival following pathogenic SIV challenge in macaques. However, an equivalent demonstration in humans is missing, and the immune correlates of HIV-1 control have been only partially characterized. We focused on the quantification of Ag-specific T cell precursors with high proliferative capacity (PHPC) using a peptide-based cultured IFN-gamma… CONTINUE READING