HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model

@inproceedings{Saba2010HIV1ST,
  title={HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model},
  author={Elisa Saba and J C Grivel and Christophe Vanpouille and Beda Brichacek and Wendy Fitzgerald and Leonid Margolis and Andrea Lisco},
  booktitle={Mucosal Immunology},
  year={2010}
}
Infection and dissemination of human immunodeficiency virus (HIV)-1 through the female body after vaginal intercourse depends on the activation/differentiation status of mucosal CD4 T cells. In this study, we investigated this status and the susceptibility to HIV-1 infection of human cervico-vaginal tissue ex vivo. We found that virtually all T cells are of the effector memory phenotype with broad CC chemokine receptor 5 (CCR5) expression. As it does in vivo, human cervico-vaginal tissue ex… CONTINUE READING