HIV-1 reverse transcriptase targeted for proteasomal degradation as a prototype vaccine against drug-resistant HIV-1.

Abstract

Acquisition of drug-resistance conferring mutations leads to an enhanced degradation of HIV-1 reverse transcriptase (RT) affecting its immunogenicity. The mechanism of this degradation is not known. We investigated the input of proteasome in this degradation, and explored a possibility to enhance the proteasomal degradation of RTs to potentiate the… (More)

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@article{Starodubova2006HIV1RT, title={HIV-1 reverse transcriptase targeted for proteasomal degradation as a prototype vaccine against drug-resistant HIV-1.}, author={Elizaveta Starodubova and Andreas Boberg and Elena Kashuba and Britta E. Wahren and Vadim Karpov and Maria G Isaguliants}, journal={Vaccine}, year={2006}, volume={24 21}, pages={4541-7} }