HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.

@article{MartinezPicado2008HIV1RT,
  title={HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.},
  author={Javier Martinez-Picado and Miguel {\'A}ngel Mart{\'i}nez},
  journal={Virus research},
  year={2008},
  volume={134 1-2},
  pages={104-23}
}
Genetic diversity plays a key role in human immunodeficiency virus (HIV) adaptation, providing a mechanism to escape host immune responses and develop resistance to antiretroviral drugs. This process is driven by the high-mutation rate during DNA synthesis by reverse transcriptase (RT), by the large viral populations, by rapid viral turnover, and by the high-recombination rate. Drugs targeting HIV RT are included in all regimens of highly active antiretroviral therapy (HAART), which helps to… CONTINUE READING
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