HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism

@inproceedings{Das2012HIV1RT,
  title={HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism},
  author={Kalyan Das and Sergio Esquembri Mart{\'i}nez and Joseph D. Bauman and Eddy Arnold},
  booktitle={Nature Structural &Molecular Biology},
  year={2012}
}
Combinations of nucleoside and non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT) are widely used in anti-AIDS therapies. Five NNRTIs, including nevirapine, are clinical drugs; however, the molecular mechanism of inhibition by NNRTIs is not clear. We determined the crystal structures of RT–DNA–nevirapine, RT–DNA, and RT–DNA–AZT-triphosphate complexes at 2.85-, 2.70- and 2.80-Å resolution, respectively. The RT–DNA complex in the crystal could bind nevirapine or AZT… CONTINUE READING

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Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
Binding of nevirapine led to opening of the NNRTI - binding pocket .
Combinations of nucleoside and non - nucleoside inhibitors ( NNRTIs ) of HIV-1 reverse transcriptase ( RT ) are widely used in anti - AIDS therapies .
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