HIV-1 rev antisense phosphorothioate oligonucleotide binding to human mononuclear cells is cell type specific and inducible.

@article{Pirruccello1994HIV1RA,
  title={HIV-1 rev antisense phosphorothioate oligonucleotide binding to human mononuclear cells is cell type specific and inducible.},
  author={Samuel J. Pirruccello and Greg A. Perry and Paul J. Bock and Molly S. Lang and Sara Noel and G. L. Zon and Patrick L. Iversen},
  journal={Antisense research and development},
  year={1994},
  volume={4 4},
  pages={285-9}
}
A fluorescein-conjugated, antisense phosphorothioate oligonucleotide with specificity for HIV-1 rev sequence (FAM-anti-rev) was investigated for its ability to bind to specific subsets of human peripheral blood mononuclear cells. Oligonucleotide binding by CD4+ and CD8+ T cells, B cells, and monocytes isolated from 15 normal and 15 HIV-infected individuals was evaluated on both nonstimulated mononuclear cells and after 24-hr activation with phytohemagglutinin (PHA). In both normals and HIV… CONTINUE READING

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