HIV-1 replication changes the function of the PKR activator PACT

@inproceedings{Clerzius2013HIV1RC,
  title={HIV-1 replication changes the function of the PKR activator PACT},
  author={Guerline Clerzius and Eileen Shaw and A{\"i}cha Daher and Samantha Burugu and Jean-François G{\'e}linas and Jean-Pierre Routy and Rekha C Patel and Anne Gatignol},
  booktitle={Retrovirology},
  year={2013}
}
Background HIV-1 translation is modulated by the activation of the interferon-inducible Protein Kinase R (PKR), which phosphorylates its downstream target, the eukaryotic translation Initiation Factor 2 (eIF2a). Phosphorylated eIF2a blocks translation initiation and consequently viral replication. PKR is not activated in HIV-1-replicating lymphocytes. Inactivated PKR allows high HIV-1 translation and may contribute to HIV-1 persistence in several cell types.