HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology.

@article{Emerman1998HIV1RG,
  title={HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology.},
  author={Michael Emerman and Michael H Malim},
  journal={Science},
  year={1998},
  volume={280 5371},
  pages={1880-4}
}
Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the… CONTINUE READING