HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques

Abstract

Rhesus macaques were immunized with attenuated vaccinia or canarypox human immunodeficiency virus type 1 (HIV-1) recombinants and boosted with HIV-1 protein subunits formulated in alum. Following challenge with HIV-2SBL6669, three out of eight immunized macaques resisted infection for six months and another exhibited significantly delayed infection, whereas all three naive controls became infected. Immunizations elicited both humoral and cellular immune responses; however, no clear correlates of protection were discerned. Although more extensive studies are now called for, this first demonstration of cross-protection between HIV-1 and -2 suggests that viral variability may not be an insurmountable problem in the design of a global AIDS vaccine.

DOI: 10.1038/nm0495-321

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@article{Abimiku1995HIV1RP, title={HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques}, author={Alash'le Abimiku and Genoveffa Franchini and James Tartaglia and Kristine Aldrich and Maria Myagkikh and Phillip D. Markham and Pele Chong and Michel Klein and Marie-Paule Kieny and Enzo Paoletti and Robert C. Gallo and Marjorie Robert-Guroff}, journal={Nature Medicine}, year={1995}, volume={1}, pages={321-329} }