HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages.

  title={HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages.},
  author={Takashi Chihara and Michihiro Hashimoto and Abu Rashed Osman and Yuka Hiyoshi-Yoshidomi and Ikuko Suzu and Nopporn Chutiwitoonchai and Masateru Hiyoshi and Seiji Okada and Shinya Suzu},
  journal={Journal of immunology},
  volume={188 8},
HIV-1 proteins, including Tat, gp120, and Nef, activate macrophages (MΦ), which is consistent with the fact that HIV-1 infection is characterized by sustained immune activation. Meanwhile, MΦ are functionally classified into two types: proinflammatory M1-MΦ and anti-inflammatory M2-MΦ. We show that HIV-1 proteins, particularly Nef, preferentially activate M2-MΦ. Extracellular Tat, gp120, and Nef activated MAPK and NF-κB pathways in human peripheral blood monocyte-derived MΦ. However, the… CONTINUE READING


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