HIV-1 protein Tat potentiation of methamphetamine-induced decreases in evoked overflow of dopamine in the striatum of the rat.

@article{Cass2003HIV1PT,
  title={HIV-1 protein Tat potentiation of methamphetamine-induced decreases in evoked overflow of dopamine in the striatum of the rat.},
  author={Wayne A. Cass and Michael E Harned and Laura E. Peters and Avindra Nath and William F. Maragos},
  journal={Brain research},
  year={2003},
  volume={984 1-2},
  pages={133-42}
}
HIV-1 infection of the brain can lead to the development of clinical syndromes reminiscent of Parkinson's disease, suggesting that HIV infection may damage nigrostriatal dopamine (DA) neurons. Although the responsible mechanisms have not been well defined, neurotoxic viral proteins, such as Tat, released from infected cells may be involved. Drug abuse is a major risk factor for contracting HIV infection. Methamphetamine (METH), a psychostimulant with high abuse potential, may also be toxic to… CONTINUE READING

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