HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells.

Abstract

OBJECTIVE Clinical experience with HIV-1 protease inhibitors (PIs) in the treatment of AIDS frequently has shown that increases in CD4+ T-cell counts can be independent of HIV-1 inhibition by these drugs. This disconnection between viral load and CD4 counts led us to investigate how the PI ritonavir directly affects leukocyte activation in vitro, using… (More)

Topics

Cite this paper

@article{Weichold1999HIV1PI, title={HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells.}, author={Frank F. Weichold and John Bryant and S. Pati and Oxana Barabitskaya and R. C. Gallo and M S Reitz}, journal={Journal of human virology}, year={1999}, volume={2 5}, pages={261-9} }