HIV-1 persistence in CD4+ T cells with stem cell-like properties

  title={HIV-1 persistence in CD4+ T cells with stem cell-like properties},
  author={Maria J Buzon and Hong Sun and Chun Li and Amy Shaw and Katherine Seiss and Zhengyu Ouyang and Enrique Martin-Gayo and Jin Leng and Timothy J Henrich and Jonathan Li and Florencia Pereyra and Ryan Zurakowski and Bruce D. Walker and E. S. Rosenberg and Xu G. Yu and Mathias Lichterfeld},
  booktitle={Nature Medicine},
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of… CONTINUE READING
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