HIV-1 persistence in CD4+ T cells with stem cell-like properties

@inproceedings{Buzon2014HIV1PI,
  title={HIV-1 persistence in CD4+ T cells with stem cell-like properties},
  author={Maria J Buzon and Hong Sun and Chun Li and Amy Shaw and Katherine Seiss and Zhengyu Ouyang and Enrique Martin-Gayo and Jin Leng and Timothy J Henrich and Jonathan Li and Florencia Pereyra and Ryan Zurakowski and Bruce D. Walker and E. S. Rosenberg and Xu G. Yu and Mathias Lichterfeld},
  booktitle={Nature Medicine},
  year={2014}
}
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 47 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 105 extracted citations

HIV-1 Reservoirs During Suppressive Therapy.

Trends in microbiology • 2016
View 3 Excerpts
Highly Influenced

T cell therapies-are T memory stem cells the answer?

Annals of translational medicine • 2015
View 14 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…