HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

@inproceedings{Chan2015HIV1LA,
  title={HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells},
  author={Chi Ngai Chan and Benjamin Trinit{\'e} and Caroline P. S. Lee and Saurabh Mahajan and Akanksha Anand and Dominik Wodarz and Steffanie Sabbaj and Anju Bansal and Paul A Goepfert and David N Levy},
  booktitle={Retrovirology},
  year={2015}
}
HIV-1 integration is prone to a high rate of failure, resulting in the accumulation of unintegrated viral genomes (uDNA) in vivo and in vitro. uDNA can be transcriptionally active, and circularized uDNA genomes are biochemically stable in non-proliferating cells. Resting, non-proliferating CD4 T cells are prime targets of HIV-1 infection and latently infected resting CD4 T cells are the major barrier to HIV cure. Our prior studies demonstrated that uDNA generates infectious virions when T cell… CONTINUE READING