HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.

@article{LpezHerrera2005HIV1IW,
  title={HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.},
  author={Albeiro L{\'o}pez-Herrera and Ying Liu and Mar{\'i}a Teresa Rugeles and Johnny J He},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1741 1-2},
  pages={55-64}
}
Astrocytes are susceptible to HIV-1 infection. We have recently demonstrated that human mannose receptor (hMR) is directly involved in CD4-independent HIV-1 infection of astrocytes. The apparent paradox between the vivid binding affinity of HIV-1 gp120 protein to hMR and the low efficiency of hMR-mediated HIV-1 infection raises the possibility that HIV-1 binding to hMR alone may negatively affect astrocyte function. In this study, we examined the relationship between HIV-1 interaction with hMR… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

HIV-1-Infected Astrocytes and the Microglial Proteome

Journal of Neuroimmune Pharmacology • 2008
View 2 Excerpts

Similar Papers

Loading similar papers…