HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.

@article{Nasr2012HIV1IO,
  title={HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.},
  author={Najla Nasr and Susan Maddocks and Stuart G. Turville and Andrew N Harman and N. E. P. Woolger and Karla J Helbig and Joanne Wilkinson and Chris R Bye and Thomas K. Wright and Dharshini Rambukwelle and Heather Donaghy and Michael R Beard and Anthony L Cunningham},
  journal={Blood},
  year={2012},
  volume={120 4},
  pages={778-88}
}
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendritic cells and CD4 T cells, without inducing any interferons. Inhibition of type I interferon induction was mediated by HIV-1 inhibition of interferon-regulated factor (IRF3) nuclear translocation. In MDMs, viperin was the most up-regulated interferon-stimulated genes, and it significantly inhibited HIV-1… CONTINUE READING