HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways.

@article{Simmons2013HIV1II,
  title={HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways.},
  author={Rachel P. Simmons and Eileen P. Scully and Erin E Groden and Kelly B. Arnold and J. Judy Chang and Kim Lane and Jeffrey D Lifson and Eric J Rosenberg and Douglas A. Lauffenburger and Marcus Altfeld},
  journal={AIDS},
  year={2013},
  volume={27 16},
  pages={2505-17}
}
OBJECTIVE To study the cytokine/chemokine profiles in response to HIV-1 viremia, and elucidate the pathways leading to HIV-1-induced inflammation. DESIGN/METHODS Plasma levels of 19 cytokines in individuals with early HIV-1 infection and individuals undergoing treatment interruptions were evaluated via multiplex assay. To investigate the cellular sources of relevant cytokines, sorted cells from HIV-1 infected individuals were assessed for mRNA expression. Relevant signaling pathways were… CONTINUE READING