HIV-1 infection in polarized primary macrophages

Background Macrophages are important targets for HIV-1 infection and are involved in mucosal transmission of the virus. Due to their ubiquitous distribution, macrophages play a crucial role in virus spread and can become reservoirs for HIV-1. In vivo, macrophages are exposed to a multiplicity of signals that can polarize them into a classically activated M1… (More)