HIV-1-infected monocytes and monocyte-derived macrophages are impaired in their ability to produce superoxide radicals.

Abstract

Monocytes and monocyte-derived macrophages play a key role in immune defense against pathogenic organisms. Superoxide anion production is a key mechanism by which phagocytes kill pathogens. We sought to determine whether human immunodeficiency virus-infected monocytes and monocyte-derived macrophages are compromised in their ability to produce the… (More)

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