HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

@article{Nazli2013HIV1GI,
  title={HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.},
  author={Aisha Nazli and Jessica K. Kafka and Victor H C Ferreira and Varun C. Anipindi and Kristen Mueller and Brendan J. W. Osborne and Sara E. Dizzell and Sarah E. Chauvin and Md Firoz Mian and Michel Ouellet and Michel J Tremblay and Karen Louise Mossman and Ali A Ashkar and Colin M. Kovacs and Dawn M. E. Bowdish and Denis P. Snider and Rupert Kaul and Charu Kaushic},
  journal={Journal of immunology},
  year={2013},
  volume={191 8},
  pages={4246-58}
}
Although women constitute half of all HIV-1-infected people worldwide (UNAIDS World AIDS Day Report, 2011), the earliest events in the female reproductive tract (FRT) during heterosexual HIV-1 transmission are poorly understood. Recently, we demonstrated that HIV-1 could directly impair the mucosal epithelial barrier in the FRT. This suggested that the HIV-1 envelope glycoprotein gp120 was being recognized by a membrane receptor on genital epithelial cells, leading to innate immune activation… CONTINUE READING