HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages

@article{Freedman2003HIV1GC,
  title={HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages},
  author={Bruce D Freedman and Qing‐Hua Liu and Manuela Del Corn{\`o} and Ronald G. Collman},
  journal={Immunologic Research},
  year={2003},
  volume={27},
  pages={261-276}
}
The chemokine receptors CCR5 and CXCR4 serve as the cellular receptors in conjunction with CD4 for HIV-1 entry and infection of target cells. Although the virus has subverted these molecules for its own use, their natural function is to respond to activation and migration signals delivered by extracellular chemokines. A principal research objective of our laboratory is to understand the consequences of virus-chemokine receptor interactions for cellular function, as well as for entry and… 
Chemokine Receptors and HIV/AIDS
TLDR
This survey has focused on the relationship certain chemokine receptors have with particular cellular systems such as lipid rafts,chemokine receptor-mediated signaling, and the actin cytoskeleton; all of which appear to play roles in or influence the establishment of HIV-1 infection.
The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration: CCR7 Homo- and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7
TLDR
It is demonstrated that a recombinant form of a viral CXCR4 ligand, X4-tropic HIV-1 gp120, enhanced the CD4 T cell response to CCR7 ligands in a manner dependent on CX CR4 and CD4, and that this effect was recapitulated by HIV- 1 virions.
Macrophages and HIV-1: dangerous liaisons.
HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef
TLDR
It is inferred that HIV-1 enhances virus spreading in confined environments by reducing T cells migration, and facilitates virus dissemination into different organs and tissues of the human body by enhancing macrophage mesenchymal migration.
Co-receptor signaling in the pathogenesis of neuroHIV
TLDR
This discussion will provide a comprehensive overview of what is known and what remains to be explored in regard to co-receptor signaling and HIV infection, and will emphasize the potential value of HIV co- receptors as a target for future therapeutic development.
R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells.
  • C. Cicala, J. Arthos, A. Fauci
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
It is suggested that R5 envelope facilitates replication of HIV in the pool of resting CD4+ T cells and signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication.
Constitutively Active CCR5 Chemokine Receptors Differ in Mediating HIV Envelope-dependent Fusion
TLDR
The results suggest that the Thr2.56(82) mutants were fully stabilized in active conformations, and the ability of constitutively active CCR5 receptors to mediate HIV envelope-directed membrane fusion is tested.
...
1
2
3
4
...

References

SHOWING 1-10 OF 86 REFERENCES
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
TLDR
It is shown that recombinant envelope proteins from macrophage-tropic HIV and SIV induce a signal through CCR5 on CD4+ T cells and that envelope-mediated signal transduction through C CR5 induces chemotaxis of T cells.
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.
In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor
HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.
TLDR
The interaction of HIV-1 gp120 with CCR5 or CXCR4 evokes complex and distinct signaling responses in primary macrophages, and gp120-evoked signals differ from those activated by the coreceptors' chemokine ligands.
Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5
TLDR
The results presented here provide the first evidence for activation of an intracellular signaling event that can initiate multiple signaling pathways as a consequence of contact between HIV-1 and chemokine receptors.
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
TLDR
The results indicate that the increased turnover of CD8+ T cells in HIV-infected subjects is mediated by the HIV envelope protein through the CXCR4 chemokine receptor.
Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation.
TLDR
It was demonstrated that exposure of peripheral blood lymphocytes to a T-cell tropic strain of HIV-1 evokes signal(s) which results in downregulation of intracellular cAMP, and pre-incubation of PBLs with the Gi-protein inhibitor Pertussis toxin mediated a significant inhibition of HIV -1 replication.
The B-Oligomer of Pertussis Toxin Deactivates Cc Chemokine Receptor 5 and Blocks Entry of M-Tropic HIV-1 Strains
TLDR
The inhibitory effect of B-oligomer on signaling from CCR5 and on entry of R5 HIV-1 strains was reversed by protein kinase C (PKC) inhibitors, indicating that B-OLigomer activity is mediated by signaling events that involve PKC.
HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.
TLDR
Data indicate that the initial interaction of HIV-1 with the monocyte is not passive, but that the binding of HIV and/or HIV- 1 gp120 to the CD4R on monocytes transduces a signal leading to transient monocyte activation.
Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5
TLDR
Western blot analyses of total cell extracts and surface proteins from multiple sets of monocytes and macrophages demonstrated substantial differences between CX CR4 molecules, indicating that the high-molecular-weight CXCR4 species in macrophage are not available for association with CD4, which may contribute to the inefficient entry of T-tropic strains into mature macrophaging.
Binding of Human Immunodeficiency Virus Type 1 to CD4 and CXCR4 Receptors Differentially Regulates Expression of Inflammatory Genes and Activates the MEK/ERK Signaling Pathway
TLDR
It is demonstrated that HIV-1 envelope glycoproteins of both T-cell-tropic and macrophagetropic strains rapidly activate the ERK/mitogen-activated protein (MAP) kinase pathway and the binding of nuclear transcription factors and stimulate expression of cytokine and chemokine genes.
...
1
2
3
4
5
...