HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by FcεRI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications

@article{Becker2004HIV1GB,
  title={HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by Fc$\epsilon$RI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications},
  author={Yechiel Becker},
  journal={Virus Genes},
  year={2004},
  volume={29},
  pages={147-165}
}
  • Y. Becker
  • Published 1 August 2004
  • Biology
  • Virus Genes
HIV-1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells and the virions shed gp120 is able to induce FcεRI+ hematopoietic… 
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7 Citations

7 Citations

The spreading of HIV-1 infection in the human organism is caused by fractalkine trafficking of the infected lymphocytes—a review, hypothesis and implications for treatment
TLDR
The present review attempts to define the role of chemokine receptors like CCR5 and CXCR4, and especially fractalkine receptor CX3CR1 in the trafficking of lymphocytes in healthy individuals and HIV-1/AIDS patients.
The Molecular Mechanism of Human Resistance to HIV-1 Infectionin Persistently Infected Individuals—A Review, Hypothesis and Implications
TLDR
The present hypothesis suggests that the HIV-1 resistant APSWs produce moreIL-4 delta 2 molecules than IL-4 molecules, which will enable to identify the individuals that have a natural resistance to HIV-l/AIDS and those who need treatments.
CpG ODNs Treatments of HIV-1 Infected Patients May Cause the Decline of Transmission in High Risk Populations – A Review, Hypothesis and Implications
TLDR
Findings from studies that reported that CpG ODNs treatment of retrovirus infected mice, monkeys and allergic mice prevented the virus and allergens caused diseases, respectively led to the hypothesis that the cure of HIV-1/AIDS patients requires the induction of endogenous synthesis of type I interferons with a bacterial C pG rich DNA that will induce the patients’ pDCs to release large amounts of type II IFNs.
HIV Infection and Adipose Tissue Resident Stem Cells: Their Involvement in Pathology and Treatment
TLDR
Disease progression during HIV infection and antiretroviral treatment is described, with a particular focus on the possible role of Adipose Tissue Resident Stem Cells as viral reservoir.
Effects of Reticuloendotheliosis Virus Infection on Cytokine Production in SPF Chickens
TLDR
Using multiplex branched DNA technology, molecular mediators that participated in the regulation of the immune response during REV infection in chickens are identified and will help understand the host immune response to virus pathogens.
Evolution of viruses and their impact on human life: HIV‐1 subgroup M
TLDR
The mechanisms used by HIV-1M to inhibit the immune system are presented and are leading to novel antiviral treatments and an approach to an HIV- 1 vaccine.
A Point of View: HIV-1/AIDS is an Allergy but CpG ODN Treatments may Inhibit Virus Replication and Reactivate the Adaptive Immunity – Hypothesis and Implications
Reevaluation of the increase in the levels of IgE and IL-4 in sera of HIV-1 infected and AIDS patients led to the suggestion that AIDS resembles allergy. Studies on the properties of the viral shed…

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