HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by FcεRI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications

@article{Becker2004HIV1GB,
  title={HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by Fc$\epsilon$RI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications},
  author={Yechiel Becker},
  journal={Virus Genes},
  year={2004},
  volume={29},
  pages={147-165}
}
  • Y. Becker
  • Published 1 August 2004
  • Biology
  • Virus Genes
HIV-1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells and the virions shed gp120 is able to induce FcεRI+ hematopoietic… 
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References

SHOWING 1-10 OF 78 REFERENCES
Binding of Human Immunodeficiency Virus Type 1 to Immature Dendritic Cells Can Occur Independently of DC-SIGN and Mannose Binding C-Type Lectin Receptors via a Cholesterol-Dependent Pathway
TLDR
It is proposed that pathways to HIV-1 attachment and uptake in DC exhibit functional redundancy; that is, they are made up of multiple independent activities that can, at least in part, compensate for one another.
HIV gp120 receptors on human dendritic cells.
TLDR
A novel biotinylated gp120 assay was used to determine whether CLR or CD4 were predominant receptors on monocyte-derived DCs and ex vivo blood DCs, and confirmed that CLRs were the major receptors for gp120 on MDDCs.
Delivery of liposome-encapsulated HIV type 1 proteins to human dendritic cells for stimulation of HIV type 1-specific memory cytotoxic T lymphocyte responses.
TLDR
Stimulation of anti-HIV-1 CTLs by this safe, inexpensive, and broadly applicable approach may be used in DC-based therapies for HIV-1 infection.
Human Immunodeficiency Virus Envelope (gp120) Binding to DC-SIGN and Primary Dendritic Cells Is Carbohydrate Dependent but Does Not Involve 2G12 or Cyanovirin Binding Sites: Implications for Structural Analyses of gp120-DC-SIGN Binding
TLDR
It is formally demonstrate that gp120 binding to DC-SIGN and MDDCs is largely if not wholly carbohydrate dependent, and evidence is provided that this enhancement may be due to cyanovirin's ability to bridge gp120 to mannosylated cell surface proteins.
Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses 1
TLDR
The effects of different Toll-like receptor (TLR)-binding compounds to enhance immune responses induced by human APCs, including CD123+ plasmacytoid DCs (PDCs, CD11c+ myeloid DCs), monocytes, and B cells are reported, providing information for the rational design of TLR ligands as adjuvants for vaccines or immune modulating therapy.
Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages
TLDR
A substantial role for MMR is suggested in the binding and transmission of HIV‐1 by macrophages and this decrease in viral longevity is due to rapid internalization of macrophage‐bound HIV.
HIV-1 viral protein R compromises cellular immune function in vivo.
TLDR
The data support that Vpr compromises antigen-specific immune responses and ultimately effector cell function, thus confirming a strong selective advantage to the virus at the expense of the host.
Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates
TLDR
The extent of resistance to viral transmission was higher in animals immunized with the ΔV3 than the WT envelope vaccine, and the protection was linked to the presence of envelope-specific CD8+ T cells, since depletion of these cells by anti-CD8 antibody treatment at the time of challenge abolished the vaccine-induced protection.
The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis.
TLDR
The AV3 mutant may redirect immune responses toward conserved epitopes of gp160, has longer expression time due to increased resistance to Ab-dependent cell-mediated cytotoxicity, and does not trigger cytopathic effects associated with apoptosis and syncytium formation.
Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21)
TLDR
The demonstration of CR2 as a receptor for HIV-1 in the presence of complement, together with the ability to enhance binding by desialylation, provides new insights into mechanisms of HIV- 1-induced immunity and immunopathogenesis.
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