HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by FcεRI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications

  title={HIV-1 gp120 Binding to Dendritic Cell Receptors Mobilize the Virus to the Lymph Nodes, but the Induced IL-4 Synthesis by Fc$\epsilon$RI+ Hematopoietic Cells Damages the Adaptive Immunity – a Review, Hypothesis, and Implications},
  author={Yechiel Becker},
  journal={Virus Genes},
  • Y. Becker
  • Published 1 August 2004
  • Biology
  • Virus Genes
HIV-1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells and the virions shed gp120 is able to induce FcεRI+ hematopoietic… 
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