HIV-1 gene expression: lessons from provirus and non-integrated DNA

@article{Wu2004HIV1GE,
  title={HIV-1 gene expression: lessons from provirus and non-integrated DNA},
  author={Yuntao Wu},
  journal={Retrovirology},
  year={2004},
  volume={1},
  pages={13 - 13}
}
Replication of HIV-1 involves a series of obligatory steps such as reverse transcription of the viral RNA genome into double-stranded DNA, and subsequent integration of the DNA into the human chromatin. Integration is an essential step for HIV-1 replication; yet the natural process of HIV-1 infection generates both integrated and high levels of non-integrated DNA. Although proviral DNA is the template for productive viral replication, the non-integrated DNA has been suggested to be active for… CONTINUE READING
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