HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.

@article{Archin2014HIV1EW,
  title={HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.},
  author={Nancy M Archin and Rosalie E Bateson and Manoj K Tripathy and Amanda M. Crooks and K. H. Yang and Noelle P. Dahl and Mary F Kearney and Elizabeth M. Anderson and John M Coffin and Matthew C. Strain and Douglas D. Richman and Kevin R. Robertson and Angela D. M. Kashuba and Ronald J. Bosch and Daria Hazuda and Joann D. Kuruc and Joseph J Eron and David M Margolis},
  journal={The Journal of infectious diseases},
  year={2014},
  volume={210 5},
  pages={728-35}
}
BACKGROUND A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4(+) T cells of treated, aviremic human immunodeficiency virus (HIV)-positive participants. The ability of multiple exposures to VOR to repeatedly disrupt latency has not been directly measured, to our knowledge. METHODS Five participants in whom resting CD4(+) T-cell-associated HIV RNA (rc-RNA) increased after a single dose of VOR agreed to receive daily VOR Monday… CONTINUE READING