HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

@article{Gringhuis2010HIV1EI,
  title={HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells},
  author={Sonja I. Gringhuis and M. J. M. van der Vlist and Linda M. van den Berg and Jeroen den Dunnen and Manja Litjens and Teunis B H Geijtenbeek},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={419-426}
}
Pattern-recognition receptors (PRRs) elicit antiviral immune responses to human immunodeficiency virus type 1 (HIV-1). Here we show that HIV-1 required signaling by the PRRs Toll-like receptor 8 (TLR8) and DC-SIGN for replication in dendritic cells (DCs). HIV-1 activated the transcription factor NF-κB through TLR8 to initiate the transcription of integrated provirus by RNA polymerase II (RNAPII). However, DC-SIGN signaling was required for the generation of full-length viral transcripts… CONTINUE READING
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