HIV-1 evades innate immune recognition through specific co-factor recruitment

  title={HIV-1 evades innate immune recognition through specific co-factor recruitment},
  author={Jane Rasaiyaah and Choon Ping Tan and Adam J. Fletcher and Amanda J. Price and Caroline Blondeau and Laura Hilditch and David A. Jacques and David L Selwood and Leo C James and Mahdad Noursadeghi and Greg J. Towers},
Human immunodeficiency virus (HIV)-1 is able to replicate in primary human macrophages without stimulating innate immunity despite reverse transcription of genomic RNA into double-stranded DNA, an activity that might be expected to trigger innate pattern recognition receptors. We reasoned that if correctly orchestrated HIV-1 uncoating and nuclear entry is important for evasion of innate sensors then manipulation of specific interactions between HIV-1 capsid and host factors that putatively… CONTINUE READING
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