HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

@article{Arthos2008HIV1EP,
  title={HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells},
  author={J. Arthos and C. Cicala and E. Martinelli and K. Macleod and D. V. Ryk and D. Wei and Z. Xiao and T. Veenstra and Thomas P Conrad and R. Lempicki and S. McLaughlin and M. Pascuccio and R. Gopaul and Jonathan P. McNally and Catherine C Cruz and Nina M Censoplano and Eva Chung and K. N. Reitano and S. Kottilil and D. Goode and A. Fauci},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={301-309}
}
Infection with human immunodeficiency virus 1 (HIV-1) results in the dissemination of virus to gut-associated lymphoid tissue. Subsequently, HIV-1 mediates massive depletion of gut CD4+ T cells, which contributes to HIV-1-induced immune dysfunction. The migration of lymphocytes to gut-associated lymphoid tissue is mediated by integrin α4β7. We demonstrate here that the HIV-1 envelope protein gp120 bound to an activated form of α4β7. This interaction was mediated by a tripeptide in the V2 loop… Expand
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