HIV-1 envelope glycan moieties modulate HIV-1 transmission.

@article{Shen2014HIV1EG,
  title={HIV-1 envelope glycan moieties modulate HIV-1 transmission.},
  author={Ruizhong Shen and Milan Ra{\vs}ka and Diane Bimczok and Jan Novak and Philip D. Coleridge Smith},
  journal={Journal of virology},
  year={2014},
  volume={88 24},
  pages={14258-67}
}
UNLABELLED The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, infectivity, antibody neutralization, and carbohydrate and receptor binding. Studies of HIV-1 glycosylation have focused mainly on the position of glycosylation, rather than the… CONTINUE READING
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