HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

@article{Dragic1996HIV1EI,
  title={HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5},
  author={Tatjana Dragic and Virginia M. Litwin and Graham Allaway and Scott R. Martin and Yaoxing Huang and Kirsten A. Nagashima and Charmagne S. Cayanan and Paul Jay Maddon and Richard A. Koup and John Percy Moore and William A. Paxton},
  journal={Nature},
  year={1996},
  volume={381},
  pages={667-673}
}
The β-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell–cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of β-chemokines. Expression of the β-chemokine receptor CC-CKR-5 in CD4+ , non-permissive human and non-human cells renders them susceptible to infection by NSI strains… 

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...

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