HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.

@article{Perelson1996HIV1DI,
  title={HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.},
  author={Alan S. Perelson and A U Neumann and Mindy Markowitz and John M. Leonard and David D. Ho},
  journal={Science},
  year={1996},
  volume={271 5255},
  pages={1582-6}
}
A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t 1/2 = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t 1/2 = 0.24 days). The estimated average total HIV-1 production was 10.3 x 10… CONTINUE READING
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