HIV-1 drug resistance and resistance testing.

  title={HIV-1 drug resistance and resistance testing.},
  author={Dana S. Clutter and Michael R. Jordan and Silvia Bertagnolio and Robert W. Shafer},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential threat to the long-term success of ART and is emerging as a threat to the elimination of AIDS as a public health problem by 2030. In this review we describe the genetic mechanisms, epidemiology, and management of HIVDR at both individual and population levels across diverse economic and geographic settings. To describe… CONTINUE READING
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