HIV-1 drug-resistance and drug-dependence

@article{Baldwin2007HIV1DA,
  title={HIV-1 drug-resistance and drug-dependence},
  author={Chris E Baldwin and Ben Berkhout},
  journal={Retrovirology},
  year={2007},
  volume={4},
  pages={78 - 78}
}
In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes an intrinsic part of the mechanism. The clinical relevance of drug-dependent HIV-1… CONTINUE READING

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Gottlinger HG: The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilinbinding drug SDZ NIM 811

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