HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism

Abstract

BACKGROUND DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL associate with the polymorphic repeated motif of BSSL exon 11. Furthermore, BSSL binds to HIV-1 co-receptor CXCR4… (More)
DOI: 10.1186/1742-4690-8-S2-P65

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