HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.

@article{Mens2010HIV1CT,
  title={HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.},
  author={Helene Mens and Mary F Kearney and Ann P Wiegand and Wei Shao and Kristian Sch\onning and Jan Gerstoft and Niels Obel and Frank M Maldarelli and John W Mellors and Thomas Benfield and John M Coffin},
  journal={Journal of virology},
  year={2010},
  volume={84 24},
  pages={12971-81}
}
Elucidating mechanisms leading to the natural control of HIV-1 infection is of great importance for vaccine design and for understanding viral pathogenesis. Rare HIV-1-infected individuals, termed HIV-1 controllers, have plasma HIV-1 RNA levels below the limit of detection by standard clinical assays (<50 to 75 copies/ml) without antiretroviral therapy. Although several recent studies have documented persistent low-grade viremia in HIV-1 controllers at a level not significantly different from… CONTINUE READING
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