HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358

@inproceedings{Bichel2013HIV1CU,
  title={HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358},
  author={Katsiaryna Bichel and Amanda J. Price and Torsten Schaller and Greg J. Towers and Stefan M. V. Freund and Leo C James},
  booktitle={Retrovirology},
  year={2013}
}
BackgroundLentiviruses such as HIV-1 can be distinguished from other retroviruses by the cyclophilin A-binding loop in their capsid and their ability to infect non-dividing cells. Infection of non-dividing cells requires transport through the nuclear pore but how this is mediated is unknown.ResultsHere we present the crystal structure of the N-terminal capsid domain of HIV-1 in complex with the cyclophilin domain of nuclear pore protein NUP358. The structure reveals that HIV-1 is positioned to… CONTINUE READING
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  • 2017
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References

Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES

Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Features and development of Coot

  • Acta crystallographica. Section D, Biological crystallography
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Flexible use of nuclear import pathways by HIV-1.

  • Cell host & microbe
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Active site remodeling switches HIV specificity of antiretroviral TRIMCyp

  • Nature Structural &Molecular Biology
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Independent evolution of an antiviral TRIMCyp in rhesus macaques.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

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